1992•OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)Requires access
Antidotal action of sodium nitrite and sodium thiosulfate against cyanide poisoning. (Reannouncement with new availability information)
Steven I. Baskin, Arthur M. Horowitz, Eric W. Nealley
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Abstract
The combination of sodium thiosulfate and sodium nitrite has been used in the United States since the 1930s as the primary antidote for cyanide intoxication. Although this combination was shown to exhibit much greater efficacy than either ingredient alone, the two compounds could not be used prophylactically because each exhibits a number of side effects. This review discusses the pharmacodynamics, pharmacokinetics, and toxicology of the individual agents, and their combination....Cyanide, Blood agent, Chemical warfare agents, Antidotes, Sodium nitrite, Sodium thiosulfate.