PENGARUH LAKTOFERIN TERHADAP PENINGKATAN TINGGI DAN LEBAR VILI USUS HALUS BAGIAN JEJUNUM PASCA ENTEREKTOMI EKSTENSIF 75

The purpose of this research is to investigate the effects of Lactoferrin on the height and width of villi jejunum small intestine post 75 % extensive enterectomy. Sample consisting of 12 local adult female cats aging of one year old and 2-2,5 kg of body weight. All experimental animals were placed in the individual cage and adapted to environmental condition for two weeks. All experimental animals were subject to 75 % extensive enterectomy. Sampling at operation day is 2 cm from jejunum small intestine was threw away. One week after 75 % extensive enterectomy, Lactoferin were orally administered 2 times daily by 1 mg/kg bw, 5 mg/kg bw, and 10 mg/kg bw respectively for group 1, group 2, group 3 and 0 mg/kg bw for control group. At day 30 after final treatment, experimental animal were secrified and 2 cm at proximal small intestine anastomosis (jejunum) was drawn for histological examination. Data were tested by using ANOVA-SPSS, according to Santoso (2001). The result of this research indicated that there were highly significant differences (p 0,05) between control group and three treatment groups of the height of villi of jejunum small intestine post 75 % extensive enterectomy. Although, the increase of width of villi of jejunum small intestine post 75 % extensive enterectomy, has not establish yet that Lactoferrin increased of width of villi of jejunum small intestine. This fact is caused on the enclosure-2, the width of villi of jejunum small intestine before the 75 % extensive enterectomy there is significant differences (p < 0,05).