Trypanosomiasis induced oxidative stress and hemato-biochemical alteration in cattle

In this present study, blood samples were collected from 10 clinically healthy and 20 adult cattle naturally infected with Trypanosomes. Blood samples were evaluated for haematological and biochemical as well as erythrocytic oxidative stress marker for both infected and control groups. The results of the study revealed substantial decrease (%) in levels of Hb (42%), PCV (39%), total protein (46%), albumin (39%), globulin (44.6%), blood glucose (46%), SOD (57.7%), CAT (62%) and increase (%) in LPO (295%), AST (70%) and ALT (4.5%) in infected cattle compared to healthy animals. Oxidative stress marker enzymes like SOD and Catalase decreased two times in infected group whereas Lipid peroxidase (LPO) increased nearly four times in infected group as compared to healthy group. Thus enhanced erythrocytic oxidation and reduction of haematological indices suggests that, trypanosome affected cattle undergoes severe oxidative stress and resultant anaemia.