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2017•International Journal of Research in DermatologyOpen access

Skin: mirror of marrow- case of POEMS syndrome

Rohidas Chavan, Vasudha Abhijit Belgaumkar, Asha Salunke, Sumegh Tharewal, Neelima Bansal

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Abstract

Monoclonal gammopathy is clonal proliferation and accumulation of immunoglobulin producing B-cells. A variety of skin disorders are associated with an increased level of monoclonal immunoglobulin proteins. Synonyms such as monoclonal gammopathies, paraproteinemias, plasma cell dyscrasias and dysproteinemias are used to designate gammaglobinopathies. Here in we report a case of POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) syndrome presenting with sclerodermoid features.

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Monoclonal gammopathy is clonal proliferation and accumulation of immunoglobulin producing B-cells. A variety of skin disorders are associated with an increased level of monoclonal immunoglobulin proteins. Synonyms such as monoclonal gammopathies, paraproteinemias, plasma cell dyscrasias and dysproteinemias are used to designate gammaglobinopathies. Here in we report a case of POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) syndrome presenting with sclerodermoid features.

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Available abstract

Monoclonal gammopathy is clonal proliferation and accumulation of immunoglobulin producing B-cells. A variety of skin disorders are associated with an increased level of monoclonal immunoglobulin proteins. Synonyms such as monoclonal gammopathies, paraproteinemias, plasma cell dyscrasias and dysproteinemias are used to designate gammaglobinopathies. Here in we report a case of POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) syndrome presenting with sclerodermoid features.

Key concepts: POEMS syndrome, Organomegaly, Dyscrasia, Monoclonal gammopathy, Paraproteinemias, Polyneuropathy, Monoclonal, Medicine

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