Antimicrobial activity of some novel triazole-3-thione containing substituted piperazine moiety

A novel series of triazole analogues possessing substituted piperazine were synthesized and their structures were elucidated using elemental analysis, IR, 1H-NMR and mass spectral data. The synthesized compounds were tested for their in-vitro antimicrobial activity against the microbial strains i.e., Staphylococcus aureus, Bacillus subtilis, Proteus mirabilis, Pseudomonas aeruginosa, Aspergillus niger and Candida albicans using disk diffusion method. Some of compounds displayed noticeable biological activity against all the pathogenic microorganisms tested including Pseudomonas aeruginosa and Candida albicans responsible for nosocomial infection. Structure activity relationship among the synthesized compounds was also studied.