2017•PubMedRequires access

[Effect and related mechanism of microRNA-181 attenuates oxidized low density lipoprotein induced vascular endothelial cell injury].

Na Wang, Xiaoqing Sun, X L Zhang, Liyin Lou, Kanan Chen, Huaixu Li, Liang Tang, W G Wang, M Zhang

Abstract

Lower miR-181 expression but higher importin-α3 and its downstream NF-κB signaling are associated with ox-LDL induced vascular endothelial cell injury and up-regulation of miR-181 could alleviate ox-LDL induced vascular endothelial cell injury possibly via importin-α3/NF-κB pathway.

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Key concepts: Endothelial stem cell, Western blot, Molecular biology, Transfection, Messenger RNA, Cell, Chemistry, microRNA