Outcome of Jaundice in neonates with ABO and Rh blood incompatibility and glucose-6-phosphate dehydrogenase deficiency

Background: Neonatal jaundice is the most common complaint in the early days of birth that can potentially results in important and irreversible effects. The aim of this study was to evaluate the severity and outcome of jaundice in newborns with ABO and Rhesus (Rh) incompatibility and glucose-6-phosphate dehydrogenase (G6PD) deficiency. Methods: Data of this cross-sectional study was collected using medical records of neonates with diagnosis of jaundice, admitted in the neonatal ward of Abuzar Teaching Hospital, located in Ahvaz, Southwest Iran. Results: Out of 1119 neonates, 272 (24.3%), 11 (1%), and 112 (10%) had ABO incompatibility, Rh incompatibility, and G6PD deficiency respectively. There was no significant difference in neonates with ABO or Rh incompatibility, and G6PD deficiency with severe hyperbilirubinemia (P=0.04). A patient with ABO incompatibility and two neonates with Rh incompatibility and five neonates with G6PD deficiency were suffering the dire consequences of neonatal jaundice (Kernicterus) that the Catching rate in the last two groups was significantly more than other neonates. Conclusion: the occurrence of jaundice in neonates with Rh incompatibility and G6PD deficiency is with dire outcomes than other neonates.