Caspofungin Sometimes Effective for Refractory Invasive Aspergillosis

Invasive aspergillosis (IA) is an increasingly common cause of nosocomial infection among immunocompromised hosts and is often fatal. Treatment options are limited to amphotericin B formulations; the triazoles itraconazole and voriconazole; and the echinocandin antifungals, including caspofungin. Caspofungin has demonstrated in vitro activity against aspergillus and efficacy in animal models of IA, …