Investigating the regulation of miRNA biogenesis and Argonaute2 by RNA binding proteins

microRNAs (miRNAs) are short ~22nt ribonucleic acids which post-transcriptionally regulate gene expression.miRNAs are key regulators of all cellular processes and the correct expression of miRNAs in an organism is crucial for proper development and cellular function.As a result, the miRNA biogenesis pathway must be highly regulated itself.In this review we outline the basic steps of miRNA biogenesis and miRNA mediated gene regulation focusing on the role of RNA binding proteins (RBPs).We also describe multiple mechanisms that regulate the canonical miRNA pathway which depend on a wide range of RBPs.Moreover, we hypothesise that the interaction between miRNA regulation and RBPs is potentially more widespread based on the analysis of available high-throughput datasets.