Syntheses of Diaryl Sulfone. IV

As a part of work on the synthesis of chemotherapeutics, diaryl sulfones were prepared. Compounds of bis (4-aminophenyl) sulfone system included bis (4-nicotinamidophenyl), bis [4-(2-hydroxy-1-naphthylazo) phenyl], bis (2-aminobenzothiazol-6-yl), bis (4-maleylamidophenyl), bis (4-succinylamidophenyl), and bis (4-phthalylamidophenyl) sulfones. Those of bis [4-hydrazinophenyl) sulfone series included bis (4-furfurylidenehydrazinophenyl), bis [4-(3-methoxy-4-hydroxybenzylidenehydrazino) phenyl], bis [4-piperonylidenehydrazinophenyl], bis (4-cinnamylidenehydrazinophenyl), and bis [4-(4-dimethylaminobenzylidenehydrazino) phenyl] sulfones. 2-Lepidyl 4-nitrophenyl sulfone and bis (2-hydroxy-3, 5-dichlorophenyl) sulfoxide were also prepared. This latter was assumed to have been formed by the steric hindrance of hydroxyl group in the ortho position, oxidation to the sulfone not having been effected.