Experimental Studies on the Purified Hepatitis Virus

By pathologic findings, the author studied the infection of purified hepatitis virus by oral administration, and compared it with those by the other infectious routes. The results are briefly summarized as follow:1) The establishment of infection by oral administration of the purified virus could be well proved by observing the pathologic findings. Compared with those caused by oral administration of the crude virus, the purified virus caused severer pathologic findings and mecroid or necrotic parts were widely observed without exception.2) The infection by the purified virus through the other routes was also well established, though it was often weaker than that through the mouth.3) Compared with that of the crued virus, the inoculation of the purified virus produced more marked pathologic findings which made the determination of infection easier.These results suggests that the application of the purified virus made the infectious exeriment a step of advance.