Assessment and comparison of 3 mortality prediction models SAPS II, APACHE II and SOFA for prediction of mortality in patients of sepsis

Background: Little is known about outcomes of patients admitted to the ICU with severe sepsis and septic shock, despite the seriousness of sepsis as a public health problem in developing countries. Understanding sepsis outcome studies is hampered by lack of an agreed severity of illness scoring system for sepsis patients. The objective of the present study is to assess and compare the validity of 3 mortality prediction models SAPS 2, APACHE II and SOFA for prediction of mortality in patients of sepsis.Methods: One hundred patients of Sepsis were selected after applying the inclusion and exclusion criteria. Informed consent was taken from the patients or their relatives A careful and detailed history was recorded to assess the onset and duration of clinical events and the probable risk factors for the same; a detailed general physical examination was performed. Blood sampling for CBC, RFT, LFT and arterial blood gas analysis was done. SAPS 2, APACHE II and SOFA scores were calculated on the day of admission.Results: The ROC analysis shows that the best discrimination was provided by SAPS 2 score (AUROC=0.981), followed by APACHE II (AUROC=0.978) and SOFA (AUROC=0.911).Conclusions: SAPS 2 score was superior to the APACHE II and SOFA scores for predicting survival in patients with septic shock but a combination of factors must be taken in consideration to estimate the prognosis in the ICU.