MP78-03 IMPACT OF RESIDUAL PERI-ORIFICE UROTHELIUM ON INTRAVESICAL RECURRENCE AFTER NEPHROURETERECTOMY FOR UPPER TRACT UROTHELIAL CANCER

You have accessJournal of UrologyBladder Cancer: Upper Tract Transitional Cell Carcinoma II1 Apr 2017MP78-03 IMPACT OF RESIDUAL PERI-ORIFICE UROTHELIUM ON INTRAVESICAL RECURRENCE AFTER NEPHROURETERECTOMY FOR UPPER TRACT UROTHELIAL CANCER Chia-Wei Cheng, Ze-Hong Lu, Weng-Horng Yang, and Chien-Hui Ou Chia-Wei ChengChia-Wei Cheng More articles by this author , Ze-Hong LuZe-Hong Lu More articles by this author , Weng-Horng YangWeng-Horng Yang More articles by this author , and Chien-Hui OuChien-Hui Ou More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.2091AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To determine the impact of residual periorifice urothelium after nephroureterectomy for primary upper tract urothelial cancer. (UTUC) METHODS We retrospectively reviewed patients with upper UTUC that had undergonenephroureterectomy. Of these 105 patients, 67 of which belonged to the study group with ipsilateral residual peri-ureteral orifice urothelium (RUO), while 38 patients served as controls with no residual peri-ureteral orifice urothelium (NUO) postoperatively by follow up cystoscopy. We analyzed intravesical recurrence, local recurrence, and survival to assess the significance between two groups. RESULTS Baseline demographics were comparable in both groups. In comparison with the RUO group, the NUO group was associated with a longer total operative time (150±78 vs.200±115 mins, p=0.03). Bladder recurrence was observed in 40 out of 67 (59.7%) in the RUO group and in 10 out of 38 (26%) in the NUO group (p=0.001) during median 39.7 months follow up. There was a significant difference in bladder cancer recurrence-free rate in the NUO group versus RUO group (p=0.04). Fifty-four percent (24/50) of first intravesical recurrence had a tendency of recurrence occurring near the area of ipsilateral ureteral orifice/scar especially in RUO group. (57.5% vs.40%, p= 0.04). Most patients (94%) in whom a bladder tumor developed postoperatively were superficial and underwent transurethral resection of the bladder tumor. The cancer specific survival rate was not significantly different when we compared the RUO and NUO groups (p =0.42). CONCLUSIONS Residual peri-ureteral orifice urothelium increased the risk of intravesical recurrence, but did not undermine survival after nephroureterectomy for primary UTUC. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e1031 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Chia-Wei Cheng More articles by this author Ze-Hong Lu More articles by this author Weng-Horng Yang More articles by this author Chien-Hui Ou More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...