Research Article Effect of Aluminium Chloride and Protective Effect of Ginger Extract on Hematological Profiles in Male Wistar Rats

The present study was planned to investigate the effect of aluminium chloride and the protective effect of ginger extract on hematological profiles in male rats. One group of rats was given aluminium chloride orally (100mg/kg bw) for 60 days, another group with aluminium chloride and ginger extract (50mg/kg bw) simultaneously and the third group with ginger extract alone. All the three groups were compared with one control group. The hematological parameters were: total erythrocytes count (RBC), White blood cells (WBC), hemoglobin(HB), hematocrit (HCT), and red blood indices: mean corpuscular volume (MCV) mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHV) was investigated. The obtained results showed significant increase in WBC count and decrease in HCT, HB and RBC. No change was noted in (MCV) and there was reduction in mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHV) in AlCl3 administered group (E1). However, no appreciable changes were noted in AlCl3 and ginger extract treated (E2) and Ginger alone treated group (E3). The changes in the values of blood indices may be a defensive mechanism against aluminum toxicity through stimulation of erythropoisis. It may be concluded that Ginger rich in antioxidant and also spicy content which is safety food for human consumption. This study showed that hematologic effects of AlCl3 are reversible by aqueous ginger extract.