Evaluation of the analgesic and antipyretic activity of various leaf extracts of Crotalaria pallida Aiton.

The present study was an attempt to investigate the analgesic & antipyretic activity of various extracts of Crotalaria pallida leaves. The analgesic activity of C.pallida extracts was evaluated on albino mice by hot plate and tail immersion methods. Where as antipyretic activity was studied on Brewer’s yeast-induced pyrexia in Wister strain albino rats.all the crude extracts of C.pallida such as ethanol, ethyl acetate, n-butanol and petroleum ether were tested for analgesic & antipyretic activity at 100 and 200mg/kg body weight. Where as pentazocine (10mg/kg) and paracetamol (100 mg/kg) were used as standard drugs for analgesic and antipyretic activities respectively.. Among all the extract n-butanol & ethyl-acetate shows significant action than other two extract in a dose of 200 mg/Kg body weight. Where as ethanol & petroleum ether extract in a dose of 200 mg/Kg body weight exhibited significant antipyretic activity after 90 minutes and 120 minutes as compared to standard paracetamol These findings demonstrate that C.pallida leaves have remarkable analgesic & antipyretic activities when compared with positive control and thus have great potential as a source for natural health .The data were verified as statistically significant by using one way ANOVA (analysis of variance) at 5% level of significance (p<0.05).