2007•Analytical chemistry, an Indian journalRequires access
Validated Simultaneous Estimation Of Rabeprazole Sodium And Itopride Hydrochloride In Pure And Pharmaceutical Capsule Formulation
Vinoth Prasanna Gunasekaran, Shishir Maheshwari, C. Roosewelt, P. Muthuprasanna, Nishalini Harikrishnan, Jean‐François Léonard
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Abstract
A simple, rapid and precise RPHPLC method was developed for the simultaneous estimation of rabeprazole sodium and itopride hydrochloride in its pure and pharmaceutical capsule formulation. A gemini C18 column(4.6mm×25cm) in isocratic mode, with mobile phase potassium dihydrogen phosphate and acetonitrile(65:35) were used. The flow rate was 1ml/min and individual components were measured at 275nm. The retention time of rabeprazole sodium and itopride hydrochloride was found to be 9.6 and 6.4min respectively. Linearity for rabeprazole sodium and itopride hydrochloride were in the range of 0.012-0.02mg/ ml and 0.09-0.21mg/ml. Amount found for rabeprazole sodium and itopride hydrochloride were found to be 19.83 and 146.22 mg/capsule respectively. Percentage recoveries for both the drugs were 100.08 and 99.82 for rabeprazole and itopride respectively. The proposed method is precise, selective and rapid for simultaneous estimation of rabeprazole sodium and itopride hydrochloride.