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Base-Free Asymmetric Transfer Hydrogenation of Aromatic Ketones

Z.-R. Dong, Y.-Y. Li, J.-S. Chen, B.-Z. Li, Y. Xing, J.-X. Gao

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Abstract

Significance A highly enantioselective hydrogenation of aromatic ketones using IrH(CO)(PPh 3 ) 3 and a tetradentate PNNP-type ligand is described. The ability to perform the reaction in the absence of base allows a wider substrate scope. A variety of other ligands (binary and PNNP-type) and metal hydride complexes were investigated.

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Significance A highly enantioselective hydrogenation of aromatic ketones using IrH(CO)(PPh 3 ) 3 and a tetradentate PNNP-type ligand is described. The ability to perform the reaction in the absence of base allows a wider substrate scope. A variety of other ligands (binary and PNNP-type) and metal hydride complexes were investigated.

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Available abstract

Significance A highly enantioselective hydrogenation of aromatic ketones using IrH(CO)(PPh 3 ) 3 and a tetradentate PNNP-type ligand is described. The ability to perform the reaction in the absence of base allows a wider substrate scope. A variety of other ligands (binary and PNNP-type) and metal hydride complexes were investigated.

Key concepts: Chemistry, Transfer hydrogenation, Hydride, Enantioselective synthesis, Base (topology), Substrate (aquarium), Noyori asymmetric hydrogenation, Ligand (biochemistry)

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