2006•Unpublished venueRequires access
Vinca alkaloid effect on microtubules of HeLa cells.
Pavlína Bečvářová, Jiřina Škorpíková, Roman Janisch, Jindřich Nový
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Abstract
The study evaluated the effect of selected vinca alkaloids on
the microtubule network of heLa cells and the recovery of its
disruption. Model experiments were used for demonstration of
the quantification of microtubule network changes induced by
vinca alkaloids using computer-assisted image analysis.
Differences in the arrangement of microtubules were assessed by
means of a software for quantification of the cytoskeleton
changes in cells treated with vincristine at a concentration of
0,020 g/l and in untreated control cells. The microtubule
network recovery process in time intervals of 6, 7, 8, 9, and
10 hours was quantified after treatment with vincristine at a
concentration of 0,020 g/l for 60 min using the software for
quantification of the cytoskeleton changes.