2006•Clinical & Experimental ImmunologyRequires access
Age dependency and mutual relations in T- and B- lymphocyteabnormalities in CVID patients
Marcela Vlková, Vojtěch Thon, Mária Šárfyová, Luděk Bláha, Adam Svobodník, J Lokaj, Jiří Litzman
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Abstract
Common variable immunodeficiency (CVID) is primary
hypogammaglobulinemia with unknown etiopathogenesis. Although
various abnormalities of T- and B-cells were described, their
pathogenetic roles are unclear. Markers associated with B-cell
development were determined on B-lymphocytes (CD19+);
T-lymphocyte development and activations markers were
determined on CD4+ and CD8+ T-lymphocytes in 42 CVID patients
and in 33 healthy controls. Abnormalities in CD4+ T-lymphocyte
activation markers (increase in CD29, HLA-DR, CD45RO, decrease
in CD27, CD62L, CD45RA) were particularly observed in patients
with a decreased number of memory (CD27+) and mature (CD21+)
B-cells (group Ia according to Freiburg classification), while
abnormalities observed in CD8+ cells (increase in CD27 and CD28
and decrease in HLA-DR, CD57 and CD38) did not depend on
grouping patients together according to B-lymphocyte
developmental subpopulations. The expression of CD27 and CD45RA
on CD4+ T-lymphocytes, such as the percentage of IgD+CD27- and
IgD+CD27+ cells in B-lymphocytes, showed age dependency to be
more significant than in the control group.