2016•UWA Profiles and Research Repository (University of Western Australia)Requires access
The clinical significance of HLA antibodies detected by solid phase assay In renal transplant recipients
Samantha Fidler
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Abstract
Kidney transplantation is the therapy of choice for end stage renal failure. One of the major immunological hurdles in transplantation is the presence of pre-formed antibodies in the recipient directed against donor HLA antigens. Donor specific anti-HLA antibodies are associated with allograft rejection and poor long term graft outcome. In recent years, the detection of anti-HLA antibodies has evolved from the relatively insensitive lymphocytotoxic crossmatch to the more sensitive solid phase assays including ELISA and Luminex bead assays. This thesis investigates the clinical significance of anti-HLA antibodies detected by Luminex single antigen bead assay on renal transplant outcome.