The Comparative Study of Aging and Auditory Evoked Potentials in the Mouse Model

Objective：Presbycusis is a progressive hearing impairment associated with aging, characterized by hearing loss and a degeneration of cochlear structures.The mouse has been a useful model of presbycusis, as it displays an accelerated age-related peripheral hearing loss.The purpose of this study is compared with aging and auditory evoked potentials in the mouse.Method：Adult male ICR mice 7, 10, 17, 23 and 27 weeks were used in this study.In order to assess age-related hearing loss (AHL), we evaluated auditory brainstem response (ABR) and auditory middle latency response (AMLR) for the evaluation of sensorineural function in peripheral auditory nerve.Results：Hearing thresholds was significantly increased 17, 23 and 27 weeks after birthing comparing with 7 weeks in the mouse.Pa latency of AMLR was no difference for 6 weeks from 23 weeks group, Absolute latency of wave IV and interpeak latency of wave I-IV were significantly delayed for 6 weeks from 23 weeks group.The result suggests that significant changes of auditory evoked potentials from 17 weeks have taken place, age-related hearing loss (AHL) could be evaluated by the shift of hearing threshold and the increasing of ABR latency in the mouse.