Beta-alanine: Design, synthesis and antimicrobial evaluation of synthesized derivatives

The present study was planned with the objective to design and synthesis esters, amides and anilides derivatives of 3-benzamido propionic acid. All the derivatives were physicochemically characterized and the assigned structures were found to be in agreement with the spectral characterization. Further, in-vitro antimicrobial evaluation of synthesized compounds against Gram positive bacteria: Staphylococcus aureus, Bacillus subtilis; Gram negative bacteria: Pseudomonas aeruginosa, Escherichia coli and fungal strains Candida albicans and Aspergillus niger was carried out by tube dilution method. Compound D14 (N-(3-(benzhydrylamino)-3-oxopropyl)benzamide) was the most effective antifungal agent among all the synthesized derivatives and possessed highest antibacterial activity against P.aeruginosa & D21 (N-(3-oxo-3-(4-bromophenylamino)propyl)benzamide) showed significant antifungal activity against C.albicans and A.niger respectively.