2016•Nanomechanics Science and Technology An International JournalRequires access
BIOSAFETY AND EFFECT OF NANOPARTICLES OF CeO2 ON METABOLIC AND PROLIFERATIVE ACTIVITY OF HUMAN MESENCHYMAL STEM CELLS IN VITRO
Anton L. Popov, Artem M. Ermakov, I. V. Savintseva, И. И. Селезнева, Р. А. Полтавцева, E. I. Zaraiskii, A. M. Poltavtsev, И. Э. Степанова, В. К. Иванов, Г. Т. Сухих
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Abstract
Clinical use of mesenchymal stem cells (MSCs) provides new prospects for treatment of most socially significant human diseases. Meanwhile, today there exist certain restrictions and difficulties in using MSCs for biomedical purposes. One of the restrictions for broad application of MSCs in cell therapy is their low proliferation rate in vitro, which increases the patient's waiting time for such treatment and, ultimately, its cost. Therefore, the search for new efficient and safe stimulators of MSC proliferation represents an urgent problem. In this work, we investigated the effect of cerium oxide (CeO2) nanoparticles on proliferative activity of human MSCs derived from human dental pulp. It was demonstrated that CeO2 nanoparticles are not toxic for human MSCs and increase their proliferation rate in vitro, simulating the level of expression of a broad range of genes responsible for the processes of proliferation, differentiation, and the cell cycle.