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2017•Open Forum Infectious DiseasesOpen access

Use of Carbapenems, Polymyxins, and Tigecycline in United States Children’s Hospitals, 2010–2014

Kathleen Chiotos, Rachael K. Ross, Jennifer Han, Matthew R. Miller, Jeffrey S. Gerber

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Abstract

We characterized use of the carbapenems, polymyxins, and tigecycline in United States children's hospitals between 2010 and 2014. We found substantial variability in use across hospitals and overall decreased use over time. Most polymyxin and tigecycline use occurred in cystic fibrosis patients, and appendectomy was a common indication for carbapenem therapy.

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We characterized use of the carbapenems, polymyxins, and tigecycline in United States children's hospitals between 2010 and 2014. We found substantial variability in use across hospitals and overall decreased use over time. Most polymyxin and tigecycline use occurred in cystic fibrosis patients, and appendectomy was a common indication for carbapenem therapy.

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Available abstract

We characterized use of the carbapenems, polymyxins, and tigecycline in United States children's hospitals between 2010 and 2014. We found substantial variability in use across hospitals and overall decreased use over time. Most polymyxin and tigecycline use occurred in cystic fibrosis patients, and appendectomy was a common indication for carbapenem therapy.

Key concepts: Tigecycline, Medicine, Polymyxin, Carbapenem, Intensive care medicine, Colistin, Polymyxin B, Antibiotics

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