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2009•Journal of Medicinal ChemistryOpen access

First Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potent and Orally Active Antitumor Agents. 2. Lead Discovery

Maria Menichincheri, Alberto Bargiotti, Jens Berthelsen, Jay Aaron Bertrand, Roberto Tiberio Bossi, Antonella Ciavolella, Alessandra Cirla, Cinzia G. Cristiani, Valter Croci, Roberto D’Alessio, Marina Fasolini, Francesco Fiorentini, Barbara Forte, Antonella Isacchi, Katia Martina, Agnese Molinari, Alessia Montagnoli, Paolo Orsini, Fabrizio Orzi, Enrico A. Pesenti, Daniele Pezzetta, Antonio Pillan, Italo Poggesi, Fulvia Roletto, Alessandra Scolaro, Marco Tatò, Marcellino Tibolla, Barbara Valsasina, Mario Varasi, Daniele Volpi, Corrado Santocanale, Ermes Vanotti

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Abstract

Binding Affinity of the Final Pair of Oxide-Bridged Phenylmorphans, the Ortho-and Para-b-Isomers and Their N-Phenethyl Analogues, and the Synthesis of the N-Phenethyl Analogues of the Ortho-and Para-d-Isomers.

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Binding Affinity of the Final Pair of Oxide-Bridged Phenylmorphans, the Ortho-and Para-b-Isomers and Their N-Phenethyl Analogues, and the Synthesis of the N-Phenethyl Analogues of the Ortho-and Para-d-Isomers.

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Available abstract

Binding Affinity of the Final Pair of Oxide-Bridged Phenylmorphans, the Ortho-and Para-b-Isomers and Their N-Phenethyl Analogues, and the Synthesis of the N-Phenethyl Analogues of the Ortho-and Para-d-Isomers.

Key concepts: Chemistry, Orally active, Lead compound, Pharmacology, Drug discovery, Lead (geology), Enzyme inhibitor, Kinase

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First Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potent and Orally Active Antitumor Agents. 2. Lead Discovery — Research Paper | ScholarLens