Prion-Dependent Changes in Protein Expression in Yeast, Saccharomyces cerevisiae

This study hopes to understand the function and possible consequences of prion proteins using Saccharomyces cerevisae and the [PSI+] phenotype as a model. Specifically, this experiment examines prion dependent changes in normal protein expression and in disabled open reading frames (dORFs) such as Pau7 and whether phenotypic changes caused by the [PSI+] prion yields a fitness advantage against normal cells under conditions of extreme environmental stress.