2013•Der pharmacia lettreRequires access

Analgesic and antipyretic effects of aqueous extract fromClerodendrum inerme (L.) Gaertn. leaves in animal models

Thirumal Margesan, Surya Srimanthula, Gollamudi S. Kishore, Vadivelan Ramachandran, Aggarwal An, Kumar

Abstract

In this study, the analgesic, and antipyretic effects of aqueous extract obtained from Clerodendrum inerme leaves, the so-called AECI was investigated. Analgesic effect of AECI was evaluated by Hot plate, Tail Flick and Tail immersion methods in albino rats. Antipyretic activity of AECI was evaluated by milk-induced hyperpyrexia in rabbits. The AECI produced significant (P<0.001) analgesic activity in all models. Further, the AECI potentiated the Diclofenac sodium-induced analgesic effect in albino rats. Treatment with AECI showed a significant (P<0.001) dose-dependent reduction of pyrexia in rabbits. The results suggest that AECI possess potent analgesic and antipyretic activity.

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Key concepts: Antipyretic, Analgesic, Diclofenac Sodium, Hot plate, Aqueous extract, Diclofenac, Traditional medicine, Chemistry