2017•Transplantation and Cellular TherapyOpen access
Haploidentical Bone Marrow Transplantation with Post-Transplant Cyclophosphamide for 41 Children and Adolescents with Bone Marrow Failures
Carmem Bonfim, Lisandro Lima Ribeiro, Samantha Nichele, Marco Antonio Bitencourt, Cilmara Cristina Kuwahara, Ana Luiza Melo Rodrigues, Gisele Loth, Noemi Farah Pereira, Alberto Cardoso Martins Lima, Mary Eapen, Ricardo Anibal Pasquini
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Abstract
The availability of matched unrelated donors as well as time to find a donor and the costs related to the acquisition of international grafts are limited in countries with ethnical minorities and fewer resources. Herein we describe the experience of 41 pts with BMF submitted to a haploidentical BMT with PT-CY between 04.2008 and 04.2016. The median age was 9 ys (range:1-16), 71% were male and 90% were CMV positive. Diagnosis: Fanconi Anemia (FA, N = 32), severe aplastic anemia (SAA, N = 5), dyskeratosis congenita (DC, N = 2) or other inherited marrow failure (N = 2).