2008•Zhonghua miniao waike zazhiRequires access
Comparison of the mucin 7 mRNA test and urine cytology for detection bladder cancer
Rongrong Zhang, Liao Hong, Guomin Tang, Yiping Lu, Lin Zhang
Open publisher page 1 citations
Abstract
Objective To compare the sensitivity and specificity of mucin 7(Muc7) mRNA test with urine cytology in detection bladder cancer.Methods In 86 patients suspected with bladder cancer,RT-PCR for Muc7 mRNA and urine cytology were conducted in the same urine samples.Fif-ty-two patients with bladder transitional cell carcinoma were confirmed histologically.The sensitivity and specificity of Muc7 mRNA and urine cytology were analyzed.Results The overall sensitivity,specificity and false positive of Mue7 mRNA test were 84.6%,85.2% and 14.7% respectively.Those of urine cytology were 34.6%,91.2% and 8.8% respectively.There were no significant differences between urine cytology and Muc7 mRNA test in the specificity and false positive; however,Muc7 mRNA had significantly higher sensitivity than urine cytology in detection of bladder cancer.Conclusion The sensitivity of Muc7 mRNA test is superior to urine cytology in detection of bladder cancer.
Key words:
Bladder neoplasms; Carcinoma; Urine; Cytodiagnosis; Mucin 7