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Observation on insulin secretion and insulin resistance in subjects with impaired glucose regulation

LI Yan-bing, Juan Liu, Wanping Deng, Liao Ying, Shao Hong, Yuan Yong-hong, Jianping Weng

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Abstract

Insulin secretion and insulin resistance were evaluated in 152 subjects with normal glucose tolerance, impaired fasting glucose (IFG) and (or) impaired glucose tolerance (IGT). The data showed that subjects with IGT exhibited an evident deficit in the early and late phases of insulin secretion after glucose load and mild insulin resistance, and subjects with IFG demostrated evident insulin resistant and a great decline in early phase insulin response and HOMA-β. Key words: Insulin secretion;  Insulin resistance;  Impaired fasting glucose;  Impaired glucose tolerance

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What this paper is about

Insulin secretion and insulin resistance were evaluated in 152 subjects with normal glucose tolerance, impaired fasting glucose (IFG) and (or) impaired glucose tolerance (IGT). The data showed that subjects with IGT exhibited an evident deficit in the early and late phases of insulin secretion after glucose load and mild insulin resistance, and subjects with IFG demostrated evident insulin resistant and a great decline in early phase insulin response and HOMA-β. Key words: Insulin secretion;  Insulin resistance;  Impaired fasting glucose;  Impaired glucose tolerance

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Available abstract

Insulin secretion and insulin resistance were evaluated in 152 subjects with normal glucose tolerance, impaired fasting glucose (IFG) and (or) impaired glucose tolerance (IGT). The data showed that subjects with IGT exhibited an evident deficit in the early and late phases of insulin secretion after glucose load and mild insulin resistance, and subjects with IFG demostrated evident insulin resistant and a great decline in early phase insulin response and HOMA-β. Key words: Insulin secretion;  Insulin resistance;  Impaired fasting glucose;  Impaired glucose tolerance

Key concepts: Internal medicine, Endocrinology, Insulin resistance, Impaired glucose tolerance, Insulin, Impaired fasting glucose, Medicine, Insulin response

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