2017•Expert Review of Gastroenterology & HepatologyRequires access
Effectiveness of interferon-free therapy for the treatment of HCV-patients with compensated cirrhosis treated through the Irish early access program
E Gray, Aisling C. O’Leary, Colm J Bergin, Mary D Cannon, Garry Courtney, Orla M. Crosbie, Cillian F De Gascun, Liam J. Fanning, Eoin R. Feeney, DD Houlihan, Barry Kelleher, John Shearer Lambert, J Lee, Patrick W. G. Mallon, Samuel J. McConkey, Peter Aiden McCormick, Susan M. McKiernan, Cora McNally, Frank Murray, G Sheehan, Stephen F. Stewart, Cathal Walsh, Suzanne Norris
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Abstract
BACKGROUND: We investigated the real-world effectiveness of interferon-free regimens for the treatment of patients with compensated cirrhosis infected with hepatitis C virus (HCV). METHOD: Using the Irish national HCV treatment registry, the effectiveness and safety of interferon-free regimens for HCV-infected patients treated between April 2015 and August 2016, was determined. RESULTS: A SVR12 was achieved in 86% of subjects treated with sofosbuvir/ledipasvir ± ribavirin (SOF/LDV±RBV), 93% treated with paritaprevir, ombitasvir and ritonavir combined with dasabuvir ± ribavirin (3D±RBV) and 89% treated with sofosbuvir/daclatasvir ± ribavirin (SOF/DCV±RBV). The discontinuation rate was 5% and the on-treatment mortality rate was 1%. CONCLUSION: The availability of interferon-free regimens represents a significant breakthrough for the treatment of HCV infection. Treatments options, with high SVR12 rates, are now available for patients with compensated cirrhosis who were unsuitable for treatment with interferon-based regimens. Data obtained from studies conducted in real world practice provide robust information fundamental for input into future economic evaluations for agents used for the treatment of HCV infection.