2011•Zhonghua neifenmi daixie zazhiRequires access

Effect of recombinant human connective tissue growth factor on the expression of membrane type-1 matrix metalloproteinase and matrix metalloproteinase 2 in human osteoblasts

Guoliang Sui, Yiqun Peng, HE Yu-ling, Mu-xu Zhai, Ling‐Qing Yuan

Abstract

Human osteoblast was treated with recombinant human connective tissue growth factor (rCTGF). This experiment showed that rCTGF increased membrane type-1 matrix metalloproteinase and matrix metalloproteinase-2 protein expression in a dose- and time-depentent manner in human osteoblasts. rCTGF induced activation of p38 MAPK in human osteoblasts. p38 MAPK inhibitor SB23058 abrogated the effect of rCTGF on the expressions of membrane type-1 matrix metalloproteinase and matrix metalloproteinase-2 in human osteoblasts. Key words: Recombinant human connective tissue growth factor; Human osteoblast; Membrane type-1 matrix metalloproteinase; Matrix metalloproteinase-2

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Key concepts: Matrix metalloproteinase, Connective tissue, Extracellular matrix, Metalloproteinase, Matrix (chemical analysis), Matrix metalloproteinase 9, Growth factor, Tissue inhibitor of metalloproteinase