Evaluation of Serum Alanine aminotransferase, Aspartateaminotransferase and Alkaline phosphatase in Adult ObeseNinava People.
Hebat-Alla A. A. Alhamdani
Abstract
Hebat-Alla A. A. Alhamdani
Abstract
Obesity is a well known cause of a lot of health problems, these problems can be further evaiuated by biochernical studies. In the present study 3 biochemical parameters represented as: Alanine aminotransferase (ALT), Aspaftate aminotransfetur. leSf; and Alkaline phosphatase (ALP) has been measured in blood of 69 apparentiy healthy obese subjects (30 males& 39 females) which divided into two subgroups according to body mass index (BMI) (30- 34.9) & (35- 39.9). The control groui intuded 32 apparently healthy with normal weight subjects. The aim of this research is to study the effect of obesity on the activity of aminotransferase enzymes (ALT& AST), and alkaline phosphatase (ALP) in Ninava compared to .o,1irol group (sr-rbjects with normal weight), in addition, to study the biochemical changes of these enzymes within obese group which classified according to the BMI and sex. According to the results which recorded in this study, there was a significant increase in the activity of ALT, AST, and ALP in obese subjects when compared to controls, also there is no significant effect of BMI on these enzymes in obese group rvith a higher mean activities of three enzymes in class II obese group (BMI 35- 39 '9). The results also showed no significant difference between male and female in obese subjects for the mean activities of these enzymes.
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Obesity is a well known cause of a lot of health problems, these problems can be further evaiuated by biochernical studies. In the present study 3 biochemical parameters represented as: Alanine aminotransferase (ALT), Aspaftate aminotransfetur. leSf; and Alkaline phosphatase (ALP) has been measured in blood of 69 apparentiy healthy obese subjects (30 males& 39 females) which divided into two subgroups according to body mass index (BMI) (30- 34.9) & (35- 39.9). The control groui intuded 32 apparently healthy with normal weight subjects. The aim of this research is to study the effect of obesity on the activity of aminotransferase enzymes (ALT& AST), and alkaline phosphatase (ALP) in Ninava compared to .o,1irol group (sr-rbjects with normal weight), in addition, to study the biochemical changes of these enzymes within obese group which classified according to the BMI and sex. According to the results which recorded in this study, there was a significant increase in the activity of ALT, AST, and ALP in obese subjects when compared to controls, also there is no significant effect of BMI on these enzymes in obese group rvith a higher mean activities of three enzymes in class II obese group (BMI 35- 39 '9). The results also showed no significant difference between male and female in obese subjects for the mean activities of these enzymes.
Key concepts: Alkaline phosphatase, Obesity, Internal medicine, Alanine aminotransferase, Body mass index, Endocrinology, Medicine, Enzyme