2017•Journal of Anesthesia and Perioperative MedicineOpen access
Effects of Sevoflurane or Propofol on Immune Function in Patients Undergoing Hepatectomy
Hao Gao, Jin‐Chao Song, Jinmin Zhang, Yingfu Jiao, Zhijie Lu, Tian-Zhu Tao, Weifeng Yu
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Abstract
Background: In this study, the effects of sevoflurane or propofol on immune function in patients undergoing partial hepatectomy were investigated during general anesthesia and after surgery.Methods: Seventy-two patients undergoing hepatectomy were randomized into sevoflurane group or propofol group. Sevoflurane or target-controlled infusion (TCI) of propofol was separately used to anesthesia induction and maintenance of two groups. Venous blood samples were taken before induction, 2 hours after anesthesia and 2 hours after surgery for measurement of the percentages of T lymphocyte (CD3+, CD4+, CD8+) and NK cells.Results: Compared with that before anesthesia induction, percentage change in CD3+ and CD4+ T cells to baseline was -0.7% and 3.8% in sevoflurane group, 10.2% and 20.2% in propofol group 2 hours after anesthesia (P=0.002 for CD3+ T cells and P=0.029 for CD4+ T cells ). Percentage change in NK cells was 17.6% in sevoflurane and -12.2% in propofol group 2 hours after anesthesia respectively (P=0.03). There was no significant difference in percentage change 2 hours after surgery of T cells and NK cells to baseline between two groups.Conclusions: Our study indicates that use of propofol during general anesthesia tend to increase the percentages of peripheral CD3+ and CD4+ cells, while sevoflurane increase the peripheral NK cells. Citation: Hao Gao, Jin-Chao Song, Jin-Min Zhang, Ying-Fu Jiao, Zhi-Jie Lu,Tian-Zhu Tao, et al. Effects of sevoflurane or propofol on immune function in patients undergoing hepatectomy. J Anesth Perioper Med 2017; 4: 1-6. doi: 10.24015/JAPM.2017.0001This is an open-access article, published by Evidence Based Communications (EBC). This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium or format for any lawful purpose. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.