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2017•Journal of Asian Natural Products ResearchRequires access

Three new anthraquinones from the twigs of Cassia fistula and their bioactivities

Min Zhou, Huan-Huan Xing, Yan Yang, Yue-De Wang, Kun Zhou, Wei Dong, Ganpeng Li, Weiyao Hu, Qiang Liu, Xuemei Li, Qiu‐Fen Hu

Open publisher page 20 citations

Abstract

Three previously unreported anthraquinones, fistulaquinones A–C (1–3), together with three known ones (4–6) were isolated from the twigs of Cassia fistula. Their structures were determined by means of extensive NMR and MS spectroscopic analyses. All the isolated compounds were tested for their anti-tobacco mosaic virus (anti-TMV) activity, and compound 3 showed significant activity with inhibition rate of 34.5% at 20 μM concentration, even more potent than positive control. Additionally, compounds 1–6 exhibited moderate cytotoxicity with IC50 values ranging from 2.8 to 9.4 μM for some tested human tumor cell lines.

About this research paper

What this paper is about

Three previously unreported anthraquinones, fistulaquinones A–C (1–3), together with three known ones (4–6) were isolated from the twigs of Cassia fistula. Their structures were determined by means of extensive NMR and MS spectroscopic analyses. All the isolated compounds were tested for their anti-tobacco mosaic virus (anti-TMV) activity, and compound 3 showed significant activity with inhibition rate of 34.5% at 20 μM concentration, even more potent than positive control. Additionally, compounds 1–6 exhibited moderate cytotoxicity with IC50 values ranging from 2.8 to 9.4 μM for some tested human tumor cell lines.

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OpenAlex reports 20 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Three previously unreported anthraquinones, fistulaquinones A–C (1–3), together with three known ones (4–6) were isolated from the twigs of Cassia fistula. Their structures were determined by means of extensive NMR and MS spectroscopic analyses. All the isolated compounds were tested for their anti-tobacco mosaic virus (anti-TMV) activity, and compound 3 showed significant activity with inhibition rate of 34.5% at 20 μM concentration, even more potent than positive control. Additionally, compounds 1–6 exhibited moderate cytotoxicity with IC50 values ranging from 2.8 to 9.4 μM for some tested human tumor cell lines.

Key concepts: Cassia, Anthraquinones, Cytotoxicity, Chemistry, Stereochemistry, Tobacco mosaic virus, Positive control, Anthraquinone

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