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Metabolic Effects of 3′-Deoxyadenosine (Cordycepin) and 2-Halo-3′-Deoxyadenosine on Repair of X-Ray-Induced Potentially Lethal Damage in Chinese Hamster V79 Cells

Wakako Hiraoka, Kiyoshi Tanabe, Mikinori Kuwabara, Fumiaki Sato

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Abstract

Using cultured Chinese hamster V79 cells, an attempt has been made to examine the phosphorylation of cordycepin and its 2-halo derivatives (2-chloro-3'-deoxyadenosine, 2-bromo-3'-deoxyadenosine, and 2-iodo-3'-deoxyadenosine) by adenosine kinase, within the cells, and to correlate it with their cytotoxicities and abilities to inhibit the repair of X-ray-induced potentially lethal damage (PLDR). Of all compounds, only cordycepin was found to be phosphorylated and showed both potent cytotoxicity and ability to inhibit PLDR.

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What this paper is about

Using cultured Chinese hamster V79 cells, an attempt has been made to examine the phosphorylation of cordycepin and its 2-halo derivatives (2-chloro-3'-deoxyadenosine, 2-bromo-3'-deoxyadenosine, and 2-iodo-3'-deoxyadenosine) by adenosine kinase, within the cells, and to correlate it with their cytotoxicities and abilities to inhibit the repair of X-ray-induced potentially lethal damage (PLDR). Of all compounds, only cordycepin was found to be phosphorylated and showed both potent cytotoxicity and ability to inhibit PLDR.

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OpenAlex reports 6 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Using cultured Chinese hamster V79 cells, an attempt has been made to examine the phosphorylation of cordycepin and its 2-halo derivatives (2-chloro-3'-deoxyadenosine, 2-bromo-3'-deoxyadenosine, and 2-iodo-3'-deoxyadenosine) by adenosine kinase, within the cells, and to correlate it with their cytotoxicities and abilities to inhibit the repair of X-ray-induced potentially lethal damage (PLDR). Of all compounds, only cordycepin was found to be phosphorylated and showed both potent cytotoxicity and ability to inhibit PLDR.

Key concepts: Cordycepin, Deoxyadenosine, Chinese hamster, Adenosine, Cytotoxicity, Adenosine kinase, Biochemistry, DNA damage

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Metabolic Effects of 3′-Deoxyadenosine (Cordycepin) and 2-Halo-3′-Deoxyadenosine on Repair of X-Ray-Induced Potentially Lethal Damage in Chinese Hamster V79 Cells — Research Paper | ScholarLens