Effect of Hydroalcoholic Extract of Boerhaavia Diffusa Linn against Cisplatin Induced Nephrotoxicity

Objective: To evaluate the Nephroprotective effect of Hydroalcoholic extract of Boerhaavia diffusa (HAEBD) in Cisplatin induced acute failure in rats. Materials & Methods: Adult female Wistar rats were divided into five groups.G1(Normal Control), G2( Toxic control), G3(Perse control with silymarin), HAEBD (200mg/kg and400mg/kg) , were adminstred orally to G4 & G5.Cisplatin was used to induce acute renal failure. The parameters studied included Serum creatinine, BUN, Urea, alkaline phosphatase & markers of oxidative stress such as renal malondialdehyde (MDA), superoxidase dismutase(SOD), glutathione(GSH), Glutathione peroxidase(GPx), catalase(CAT) in renal cortical homogenates. Histopathological examination also carried out Results: The results revealed that HAEBD treatment significantly reduced blood urea and serum creatinine levels elevated by CP administration Furthermore HAEBD significantly attenuated CP induced increase in MDA & decrease in reduced GSH, and CAT & SOD and GSH peroxidase activities in renal cortical homogenates. Additionally histopathological examination showed that HAEBD markedly ameliorated CP induced renal tubular necrosis. Conclusion: The results indicate that the aerial parts of Boerhaavia diffusa are endowed with Nephroprotective effect.