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2017•Journal of Neurogastroenterology and MotilityOpen access

Maturation Phenotype of Peripheral Blood Monocyte/Macrophage After Stimulation with Lipopolysaccharides in Irritable Bowel Syndrome

Óscar Rodríguez, Joselín Hernández-Ruiz, Yolanda López‐Vidal, Luis Charúa-Guindic, Galileo Escobedo, Max J. Schmulson

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Abstract

BACKGROUND/AIMS: lipopolysaccharides (LPS), in vitro. METHODS: < 0.05. RESULTS: < 0.001). CONCLUSIONS: The initial phase of monocyte/macrophage maturation appears to be more advanced in IBS compared to controls. However, the decreased CX3CR1 in patients with IBS, compared to controls, when stimulated with LPS suggests a state of immune activation in IBS.

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BACKGROUND/AIMS: lipopolysaccharides (LPS), in vitro. METHODS: < 0.05. RESULTS: < 0.001). CONCLUSIONS: The initial phase of monocyte/macrophage maturation appears to be more advanced in IBS compared to controls. However, the decreased CX3CR1 in patients with IBS, compared to controls, when stimulated with LPS suggests a state of immune activation in IBS.

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Available abstract

BACKGROUND/AIMS: lipopolysaccharides (LPS), in vitro. METHODS: < 0.05. RESULTS: < 0.001). CONCLUSIONS: The initial phase of monocyte/macrophage maturation appears to be more advanced in IBS compared to controls. However, the decreased CX3CR1 in patients with IBS, compared to controls, when stimulated with LPS suggests a state of immune activation in IBS.

Key concepts: CD14, CD11c, Medicine, Peripheral blood mononuclear cell, Irritable bowel syndrome, Immune system, Immunology, CX3CR1

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