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2016•Transactions of the Royal Society of Tropical Medicine and HygieneRequires access

Low efficacy of albendazole againstTrichuris trichiurainfection in schoolchildren from Port Elizabeth, South Africa

Ivan Müller, Lindsey Beyleveld, Markus Gerber, Uwe Pühse, Rosa du Randt, Jürg Utzinger, Leyli Zondie, Cheryl Walter, Peter Steinmann

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Abstract

BACKGROUND: Albendazole is one of two standard drugs for the control of soil-transmitted helminthiasis. METHODS: A total of 149 schoolchildren from Port Elizabeth, South Africa, were examined for soil-transmitted helminth infections using duplicate Kato-Katz thick smears before and 2 weeks after administration of albendazole (400 mg). RESULTS: Trichuris trichiura was the predominant soil-transmitted helminth species (prevalence 60.4%), followed by Ascaris lumbricoides (47.7%). While albendazole was highly efficacious against A. lumbricoides (cure rate [CR] 97.2%; egg reduction rate [ERR] 94.3%), it lacked efficacy against T. trichiura (CR 1.1%; ERR 46.0%). CONCLUSIONS: Our study confirms low efficacy of single dose albendazole against T. trichiura. There is a need for safe and efficacious drugs against T. trichiura.

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What this paper is about

BACKGROUND: Albendazole is one of two standard drugs for the control of soil-transmitted helminthiasis. METHODS: A total of 149 schoolchildren from Port Elizabeth, South Africa, were examined for soil-transmitted helminth infections using duplicate Kato-Katz thick smears before and 2 weeks after administration of albendazole (400 mg). RESULTS: Trichuris trichiura was the predominant soil-transmitted helminth species (prevalence 60.4%), followed by Ascaris lumbricoides (47.7%). While albendazole was highly efficacious against A. lumbricoides (cure rate [CR] 97.2%; egg reduction rate [ERR] 94.3%), it lacked efficacy against T. trichiura (CR 1.1%; ERR 46.0%). CONCLUSIONS: Our study confirms low efficacy of single dose albendazole against T. trichiura. There is a need for safe and efficacious drugs against T. trichiura.

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Available abstract

BACKGROUND: Albendazole is one of two standard drugs for the control of soil-transmitted helminthiasis. METHODS: A total of 149 schoolchildren from Port Elizabeth, South Africa, were examined for soil-transmitted helminth infections using duplicate Kato-Katz thick smears before and 2 weeks after administration of albendazole (400 mg). RESULTS: Trichuris trichiura was the predominant soil-transmitted helminth species (prevalence 60.4%), followed by Ascaris lumbricoides (47.7%). While albendazole was highly efficacious against A. lumbricoides (cure rate [CR] 97.2%; egg reduction rate [ERR] 94.3%), it lacked efficacy against T. trichiura (CR 1.1%; ERR 46.0%). CONCLUSIONS: Our study confirms low efficacy of single dose albendazole against T. trichiura. There is a need for safe and efficacious drugs against T. trichiura.

Key concepts: Trichuris trichiura, Albendazole, Ascaris lumbricoides, Trichuriasis, Medicine, Trichuris, Port harcourt, Veterinary medicine

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