A Retrospective Study to Identify Novel Prognostic Factors for Glioblastoma Patients Survival: Survival Outcomes Prognostication in Glioblastoma Diagnosed Patients (P5.085)

Objective: To examine the prognostic value of primary tumor sites on survival among different racial groups of glioblastoma diagnosed patients. Background: Glioblastoma is the most common and aggressive primary brain tumor, harboring a dismal survival rates. Prognostication outcomes remains a challenge of brain cancer treatment. There remains controversy over the currently known prognostic factors that have been utilized to predict outcome. Methods: 645 clinically diagnosed cases of GBM were obtained from the Scott & White Memorial Hospital Brain Tumor Registry and were histologically categorized. The data were stratified according to sex, age, ethnicity, primary tumor site, vital status, and survival rate in years. Results: The Black population has a relatively low incidence of GBM (5.9[percnt]) and the greatest overall survival rate vs. all other race groups (47.4[percnt] vs. 7.3[percnt], p<0.01). The White population has a highest GBM incidence (87.1[percnt]) and the lowest overall survival rate vs. all other (6.6[percnt] vs. 30.1[percnt], p<0.01). Survival correlated with tumors in the temporal lobe (25.8[percnt] vs. 20.2[percnt], p=0.30), in the occipital lobe (8.1[percnt] vs. 2.9[percnt], p=0.05), and the parietal lobe (24.2[percnt] vs. 20.8[percnt], p=0.53). Survival was lower in brain overlapping (4.8[percnt] vs. 10.6[percnt], p=0.15) and brain NOS (4.8[percnt] vs. 10.1[percnt], p=0.18). The overall survival rate for males was greater than for females (62.9[percnt] vs. 37.1[percnt], p=0.12). Conclusions: Besides ethnicity, which alone can serve as a prognostic factor for the survival of GBM patients, primary tumor site is an additional and novel tool for more accurate prediction of survival. Black racial background and location of primary tumor in the temporal, occipital, or parietal lobes are strong positive predictors of survival. Conversely, patients of White racial background and primary tumor site locations in the brain overlapping and brain NOS areas were negative predictors of survival; those individuals were the most vulnerable to disease.