2016•Blood AdvancesOpen access

Genetic analysis of B-cell lymphomas associated with hemophagocytic lymphohistiocytosis

Kruti Patel, Sophia S. Lee, Poojitha Valasareddy, Namratha Reddy Vontela, Philippe Prouet, Mike G. Martin

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Abstract

TO THE EDITOR: Hemophagocytic lymphohistiocytosis (HLH) is an aggressive, life-threatening syndrome of excessive immune activation. HLH clinically presents with fever, pancytopenia, splenomegaly, and hemophagocytosis in the bone marrow, lymph nodes, or liver. A proposed mechanism for HLH is a

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TO THE EDITOR: Hemophagocytic lymphohistiocytosis (HLH) is an aggressive, life-threatening syndrome of excessive immune activation. HLH clinically presents with fever, pancytopenia, splenomegaly, and hemophagocytosis in the bone marrow, lymph nodes, or liver. A proposed mechanism for HLH is a

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Available abstract

TO THE EDITOR: Hemophagocytic lymphohistiocytosis (HLH) is an aggressive, life-threatening syndrome of excessive immune activation. HLH clinically presents with fever, pancytopenia, splenomegaly, and hemophagocytosis in the bone marrow, lymph nodes, or liver. A proposed mechanism for HLH is a

Key concepts: Hemophagocytosis, Hemophagocytic lymphohistiocytosis, Pancytopenia, Medicine, Bone marrow, Immunology, Pathology, Disease

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