2016•Journal of Huntington s DiseaseOpen access

Targeting the Cholinergic System to Develop a Novel Therapy for Huntington’s Disease

Gary X. D’Souza, Henry J. Waldvogel

Abstract

In this review, we outline the role of the cholinergic system in Huntington's disease, and briefly describe the dysfunction of cholinergic transmission, cholinergic neurons, cholinergic receptors and cholinergic survival factors observed in post-mortem human brains and animal models of Huntington's disease. We postulate how the dysfunctional cholinergic system can be targeted to develop novel therapies for Huntington's disease, and discuss the beneficial effects of cholinergic therapies in pre-clinical and clinical studies.

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Key concepts: Cholinergic, Huntington's disease, Cholinergic system, Neuroscience, Disease, Cholinergic neuron, Dysfunctional family, Medicine