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2016•Bioorganic & Medicinal Chemistry LettersOpen access

Novel trifluoromethylated 9-amino-3,4-dihydroacridin-1(2H)-ones act as covalent poisons of human topoisomerase IIα

Lorena Infante Lara, Alexis Sledge, Amine M. Laradji, Cosmas O. Okoro, Neil Osheroff

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Key concepts: Amsacrine, Topoisomerase, Chemistry, Cleavage (geology), Acridine, DNA, Enzyme, Stereochemistry

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Novel trifluoromethylated 9-amino-3,4-dihydroacridin-1(2H)-ones act as covalent poisons of human topoisomerase IIα — Research Paper | ScholarLens