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Development and comparison of liposomes and nanocapsules as injectable nanocarriers for poorly aqueous soluble drugs

Reatul Karim, C Pallazo, Julie Laloy, Élise Lepeltier, Anne-Sophie Delvigne, Jean‐Michel Dogné, Brigitte Évrard, Catherine Passirani-Malleret, Géraldine Piel

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Abstract

About 90% of drugs in development phase have poor aqueous solubility. Liposomes and nanocapsules are promising approaches that enable parenteral administration of these drugs with possibilities of site specific delivery. The objective of the study was to develop different liposomes and lipid nanocapsules entrapping a hydrophobic model molecule (apigenin (AG)), and to characterize and compare them as potential injectable nanocarriers (NCs) for drugs with low aqueous solubility.

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What this paper is about

About 90% of drugs in development phase have poor aqueous solubility. Liposomes and nanocapsules are promising approaches that enable parenteral administration of these drugs with possibilities of site specific delivery. The objective of the study was to develop different liposomes and lipid nanocapsules entrapping a hydrophobic model molecule (apigenin (AG)), and to characterize and compare them as potential injectable nanocarriers (NCs) for drugs with low aqueous solubility.

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Available abstract

About 90% of drugs in development phase have poor aqueous solubility. Liposomes and nanocapsules are promising approaches that enable parenteral administration of these drugs with possibilities of site specific delivery. The objective of the study was to develop different liposomes and lipid nanocapsules entrapping a hydrophobic model molecule (apigenin (AG)), and to characterize and compare them as potential injectable nanocarriers (NCs) for drugs with low aqueous solubility.

Key concepts: Nanocarriers, Nanocapsules, Liposome, Aqueous solution, Nanotechnology, Chemistry, Pharmacology, Materials science

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Development and comparison of liposomes and nanocapsules as injectable nanocarriers for poorly aqueous soluble drugs — Research Paper | ScholarLens