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IN VITRO CYTOTOXIC ACTIVITY OF INDIAN MEDICINAL PLANTS USED TRADITIONALLY TO TREAT CANCER

Shanthy Sundaram, Satish Kumar Verma, Priyanka Dwivedi

Open publisher page 10 citations

Abstract

The SRB assay was used to test in vitro cytotoxicity against four human cancer cell lines of six Indian medicinal plant species which are  being used by traditional people in tribal regions for the treatment of ulcers and other diseases of patients. The ethanolic and aqueous extracts were tested against human cancer cell lines such as human neuroblastoma cell line (IMR‐32) and colon cell lines (HT‐15 & HT‐29) and lung cancer cell lines A‐ 549. The results showed that plants Calotropis procera, Ocimum sanctum and Cannabis sativa, exhibited a very high degree of in vitro cytotoxic activity. The results showed a certain degree of selectivity against the different cell types with different extracts.

About this research paper

What this paper is about

The SRB assay was used to test in vitro cytotoxicity against four human cancer cell lines of six Indian medicinal plant species which are  being used by traditional people in tribal regions for the treatment of ulcers and other diseases of patients. The ethanolic and aqueous extracts were tested against human cancer cell lines such as human neuroblastoma cell line (IMR‐32) and colon cell lines (HT‐15 & HT‐29) and lung cancer cell lines A‐ 549. The results showed that plants Calotropis procera, Ocimum sanctum and Cannabis sativa, exhibited a very high degree of in vitro cytotoxic activity. The results showed a certain degree of selectivity against the different cell types with different extracts.

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OpenAlex reports 10 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The SRB assay was used to test in vitro cytotoxicity against four human cancer cell lines of six Indian medicinal plant species which are  being used by traditional people in tribal regions for the treatment of ulcers and other diseases of patients. The ethanolic and aqueous extracts were tested against human cancer cell lines such as human neuroblastoma cell line (IMR‐32) and colon cell lines (HT‐15 & HT‐29) and lung cancer cell lines A‐ 549. The results showed that plants Calotropis procera, Ocimum sanctum and Cannabis sativa, exhibited a very high degree of in vitro cytotoxic activity. The results showed a certain degree of selectivity against the different cell types with different extracts.

Key concepts: Traditional medicine, Cytotoxic T cell, Cancer, Medicinal plants, In vitro, Biology, Medicine, Genetics

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IN VITRO CYTOTOXIC ACTIVITY OF INDIAN MEDICINAL PLANTS USED TRADITIONALLY TO TREAT CANCER — Research Paper | ScholarLens