PREPARATION AND CHARACTERIZATION OF LORNOXICAM SOLID SYSTEMS USING CYCLODEXTRINS FOR IMPROVED BIOAVAILABILITY

The specific objectives of the investigation was to enhance the dissolution rate and bioavailability of the NSAID (lornoxicam), by Cyclodextrin complexation and to study the complexation of the selected NSAID with α-CD, β-CD and HP-β-CD. The DSC, SEM, and XRD studies indicated a reduction in crystallanity and partial amorphization of the lornoxicam because of the formation of inclusion complexes with cyclodextrins. Drugs formed inclusion complexes with β-CD, HP-β-CD, and α-CD at a 1:1 M ratio in solution. The complexes formed were quite stable. The solubility and dissolution rate of all the anti inflammatory drugs studied were markedly enhanced by complexation with α-CD, β- CD and HP-β-CD. Studies concluded that all ternary systems, showed significantly better dissolution parameters than that of the corresponding binary systems.