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2016•Obstetric Anesthesia DigestRequires access

In Vitro Comparative Effect of Carbetocin and Oxytocin in Pregnant Human Myometrium With and Without Oxytocin Pretreatment

Naida M. Cole, J.C.A. Carvalho, Magda Erik‐Soussi, N. Ramachandran, Mrinalini Balki

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Abstract

(Anesthesiology 2016;124:378–386) Oxytocin remains the first-line uterotonic agent for the prevention and treatment of postpartum hemorrhage (PPH) secondary to uterine atony, but its routine use has limitations that include many side effects. Hence there is a search for newer agents for the prevention of PPH with greater efficacy and fewer side effects. The objective of this study was to compare the effects of oxytocin and carbetocin in human term pregnant myometrium in vitro, with and without oxytocin pretreatment.

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What this paper is about

(Anesthesiology 2016;124:378–386) Oxytocin remains the first-line uterotonic agent for the prevention and treatment of postpartum hemorrhage (PPH) secondary to uterine atony, but its routine use has limitations that include many side effects. Hence there is a search for newer agents for the prevention of PPH with greater efficacy and fewer side effects. The objective of this study was to compare the effects of oxytocin and carbetocin in human term pregnant myometrium in vitro, with and without oxytocin pretreatment.

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Available abstract

(Anesthesiology 2016;124:378–386) Oxytocin remains the first-line uterotonic agent for the prevention and treatment of postpartum hemorrhage (PPH) secondary to uterine atony, but its routine use has limitations that include many side effects. Hence there is a search for newer agents for the prevention of PPH with greater efficacy and fewer side effects. The objective of this study was to compare the effects of oxytocin and carbetocin in human term pregnant myometrium in vitro, with and without oxytocin pretreatment.

Key concepts: Uterotonic, Oxytocin, Uterine atony, Medicine, Myometrium, Obstetrics, Uterus, Gynecology

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