2017•European Journal of DermatologyRequires access
Mixed connective tissue disease with bilateral erythematous palpebral oedema and targetoid skin lesions
Masanobu Sakaguchi, Tomoki Takeda, Takao Kodera, Kazuhiro Murakami, Masahiro Oka
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Abstract
Mixed connective tissue disease (MCTD) is a rare connective tissue disease with an autoimmune background. Clinically, it is characterised by manifestations shared with other connective tissue diseases; systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and polymyositis/dermatomyositis [1, 2]. High titres of distinct serum autoantibodies to the U1 small nuclear ribonucleoprotein (RNP) are characteristic of MCTD. Several skin manifestations of MCTD are known, including Raynaud's phenomenon, [...]