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2016•Unpublished venueRequires access

EXPRESSION OF CALCITONIN GENE RELATED PEPTIDE (CGRP) IN SMALL NEURONS OF TRIGEMINAL GANGLION AND ITS IMPLICATIONS IN MIGRAINE

Sankaran Pk, Vinay Jadhav, Sri Lakshminarayana

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Abstract

CGRP is a neuropeptide present in the central and peripheral nervous system that has diverse functions as primary afferent neurotransmitter which is important in nociception. Migraine is a neurovascular disorder involving trigeminal ganglion characterized by recurrent episodic headache and a rise in levels of CGRP in plasma. In this study expression of CGRP was studied in neurons of trigeminal ganglion in male wistar albino rats. CGRP is expressed in cytoplasm of neurons mainly in the small sized neurons indicating that small sized neurons are involved in nociception. KEYWORD: neuropeptide, migraine, small sized neurons.

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What this paper is about

CGRP is a neuropeptide present in the central and peripheral nervous system that has diverse functions as primary afferent neurotransmitter which is important in nociception. Migraine is a neurovascular disorder involving trigeminal ganglion characterized by recurrent episodic headache and a rise in levels of CGRP in plasma. In this study expression of CGRP was studied in neurons of trigeminal ganglion in male wistar albino rats. CGRP is expressed in cytoplasm of neurons mainly in the small sized neurons indicating that small sized neurons are involved in nociception. KEYWORD: neuropeptide, migraine, small sized neurons.

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Available abstract

CGRP is a neuropeptide present in the central and peripheral nervous system that has diverse functions as primary afferent neurotransmitter which is important in nociception. Migraine is a neurovascular disorder involving trigeminal ganglion characterized by recurrent episodic headache and a rise in levels of CGRP in plasma. In this study expression of CGRP was studied in neurons of trigeminal ganglion in male wistar albino rats. CGRP is expressed in cytoplasm of neurons mainly in the small sized neurons indicating that small sized neurons are involved in nociception. KEYWORD: neuropeptide, migraine, small sized neurons.

Key concepts: Calcitonin gene-related peptide, Trigeminal ganglion, Neuropeptide, Nociception, Neuroscience, Ganglion, Substance P, Endocrinology

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EXPRESSION OF CALCITONIN GENE RELATED PEPTIDE (CGRP) IN SMALL NEURONS OF TRIGEMINAL GANGLION AND ITS IMPLICATIONS IN MIGRAINE — Research Paper | ScholarLens