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2016•Natural Product ResearchRequires access

Furofuran lignan glucosides from the leaves of Vitex negundo var. cannabifolia

Yueting Li, Manman Li, Jing Sun, Zhixiang Zhu, Yuelin Song, Dao-Ran Pang, Jiao Zheng, Yunfang Zhao, Pengfei Tu, Jun Li

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Abstract

Two new furofuran lignan glucosides, cannabilignin (1) and isocannabilignin (2), together with four known compounds (3–6), were isolated from the leaves of Vitex negundo var. cannabifolia. The structures of the isolates were elucidated by analysis of spectroscopic data. Compound 3 exhibited weak inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC50 value of 69.1 ± 5.8 μM.

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What this paper is about

Two new furofuran lignan glucosides, cannabilignin (1) and isocannabilignin (2), together with four known compounds (3–6), were isolated from the leaves of Vitex negundo var. cannabifolia. The structures of the isolates were elucidated by analysis of spectroscopic data. Compound 3 exhibited weak inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC50 value of 69.1 ± 5.8 μM.

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Available abstract

Two new furofuran lignan glucosides, cannabilignin (1) and isocannabilignin (2), together with four known compounds (3–6), were isolated from the leaves of Vitex negundo var. cannabifolia. The structures of the isolates were elucidated by analysis of spectroscopic data. Compound 3 exhibited weak inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC50 value of 69.1 ± 5.8 μM.

Key concepts: Lignan, Vitex negundo, Chemistry, Glucoside, Traditional medicine, Botany, Organic chemistry, Biology

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